Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyrimidin-5-yl)urea | Drug Info |
| mTOR --- PI3K gamma | tert-Butyl 4-(6-(4-(3-Methylureido)phenyl)-4-morpholino-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(3-Cyclopropyl-7-morpholino-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(pyridin-3-yl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(2-(3-(hydroxymethyl)phenyl)-6-morpholino-9H-purin-9-yl)piperidin-1-yl)ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-Dimethylaminophenyl)-3-[4-(3-isopropyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]-urea | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide | Drug Info |
| mTOR --- PI3K gamma | N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-thiophen-2-ylurea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(oxetan-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 5-(6-morpholino-9-(piperidin-4-yl)-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-isopropoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-Chlorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea | Drug Info |
| mTOR --- PI3K gamma | (3-(4-morpholino-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-fluorophenyl)urea | Drug Info |
| mTOR --- PI3K gamma | methyl 4-(3-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)ureido)benzoate | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-3-yl)urea | Drug Info |
| mTOR --- PI3K gamma | tert-butyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | methyl 4-(6-{4-[(cyclopropylcarbamoyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-p-tolylurea | Drug Info |
| mTOR --- PI3K gamma | 4-[3-{4-(4,6-Dimorpholino-1,3,5-triazin-2yl)-phenyl}ureido]benzoic Acid | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-phenylurea | Drug Info |
| mTOR --- PI3K gamma | 3-(4-morpholino-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(4-(8-methyl-8-azabicyclo[3.2.1]octan-3-yloxy)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((2-(naphthalen-2-yl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(3,4-dimethoxyphenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(2-(4-methylpiperazin-1-yl)ethyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 2-((2-(4-chlorophenyl)-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | N-Ethyl-4-({[4-(3-ethyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)benzamide | Drug Info |
| mTOR --- PI3K gamma | 3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | tert-butyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | Drug Info |
| mTOR --- PI3K gamma | (2,4-Difluorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea | Drug Info |
| mTOR --- PI3K gamma | 5-(9-(1-((6-fluoropyridin-3-yl)methyl)piperidin-4-yl)-6-morpholino-9H-purin-2-yl)pyridin-3-ol | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1,2-dimethyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | [4-(3-Methyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-(2-thienyl)urea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-((1S,5S,6S)-6-hydroxy-3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-phenyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1-(3-(4-methylpiperazin-1-yl)propyl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-pyridazin-4-ylurea | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-hydroxyethyl)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 2-((1-(3-(dimethylamino)propyl)-5-methoxy-2-methyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(dimethylamino)phenyl)urea | Drug Info |
| mTOR --- PI3K gamma | 4-(6-morpholino-9H-purin-2-yl)phenol | Drug Info |
| mTOR --- PI3K gamma | (3-(1-(1-benzylpiperidin-4-yl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)methanol | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(4,6-Dimorpholin-4-yl-1,3,5-triazin-2-yl)-phenyl]-3-[4-(1-hydroxyethyl)phenyl]urea | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| mTOR --- PI3K gamma | (S)-N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-morpholino-6-((tetrahydrofuran-3-yl)oxy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide | Drug Info |
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