Resistance mutation info of target

Target General Information
Target ID T88240
Target Name Bacterial Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (DHPS) Target Info
Gene Name folP
Species Escherichia coli
Uniprot ID DHPS_ECOLI
Sequence MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGE
STRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSL
SEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKE
KLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSL
ACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE [Escherichia coli
]
Drug Resistance Mutation and Corresponding Drugs
Ref 521417ClinicalTrials.gov (NCT00000802) A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides. U.S. National Institutes of Health.
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Mutation Info Missense: A587V
Drugs
Drug Name Sulfadiazine Drug Info [555650]
Targeted Disease Toxoplasmosis
Mutation Info Missense: F25I
Drugs
Drug Name Sulfonamide Drug Info [556229]
Targeted Disease Bacterial infection
Mutation Info Missense: K540E
Drugs
Drug Name Sulfamethoxazole Drug Info [555795]
Targeted Disease Plasmodium Falciparum Malaria
Mutation Info Missense: K540N
Drugs
Drug Name Sulfamethoxazole Drug Info [555795]
Targeted Disease Plasmodium Falciparum Malaria
Mutation Info Missense: P55A
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: P55H
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: P55L
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: P55R
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: P55S
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: P55T
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: P64A
Drugs
Drug Name Sulfonamide Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: P64H
Drugs
Drug Name Sulfonamide Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: P64L
Drugs
Drug Name Sulfonamide Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: P64R
Drugs
Drug Name Sulfonamide Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: P64S
Drugs
Drug Name Sulfonamide Drug Info [556243]
Targeted Disease Bacterial infection
Mutation Info Missense: T53A
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: T53I
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: T53N
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Mutation Info Missense: T53P
Drugs
Drug Name Dapsone Drug Info [556243]
Targeted Disease Hansen disease
Reference
Ref 555650In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone. Antimicrob Agents Chemother. 2008 Apr;52(4):1269-77. doi: 10.1128/AAC.01203-07. Epub 2008 Jan 22.
Ref 555795Novel K540N mutation in Plasmodium falciparum dihydropteroate synthetase confers a lower level of sulfa drug resistance than does a K540E mutation. Antimicrob Agents Chemother. 2011 May;55(5):2481-2. doi: 10.1128/AAC.01394-10. Epub 2011 Feb 22.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.

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