Target Information

Target General Infomation
Target ID
T29303
Former ID
TTDS00155
Target Name
Sodium channel
Gene Name
SCN1A
Synonyms
NAC1; SCN1; Sodium channel protein type I subunit alpha; Sodium channel protein, brain I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; SCN1A
Target Type
Successful
Disease Angina pectoris [ICD9: 413; ICD10: I20]
Anesthesia [ICD9: 338; ICD10: R20.0]
Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10: F31, F40-F42]
Cystic fibrosis [ICD9: 277; ICD10: E84]
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63]
Cough [ICD9: 786.2; ICD10: R05]
Cardiac failure [ICD10: I50]
Cardiovascular disorder [ICD10: I00-I99]
Cerebral infarction [ICD10: I63]
Cardiac arrhythmias [ICD9: 427; ICD10: I47-I49]
Diabetes [ICD9: 253.5, 588.1; ICD10: E23.2, N25.1]
Epileptic seizures [ICD9: 345.9, 780.3; ICD10: G40, P90, R56]
Epilepsy [ICD10: G40]
Epilepsy; Focal; Seizure disorder [ICD9: 345, 345.4, 345.5, 345.9, 780.3; ICD10: G40, G40.2, P90, R56]
Gastric cancer [ICD9: 151; ICD10: C16]
Heart arrhythmia [ICD10: I47-I49]
Infections with sarcoptes scabiei [ICD9: 133; ICD10: B86]
Ischemia [ICD9: 459.89; ICD10: I99.8]
Local or regional analgesia and anesthesia [ICD10: R20.0]
Migraine [ICD9: 346; ICD10: G43]
Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10: I21, I22, R52, R52.1-R52.2, R60.9, G89]
Nerve injury [ICD10: T14.4]
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Overactive bladder disorder [ICD9: 188, 596.51; ICD10: C67, N32.81]
Oxytocic [ICD10: O00-O99]
Osteoarthritis [ICD9: 715; ICD10: M15-M19, M47]
Peripheral neuropathy [ICD10: G64]
Parkinson's disease [ICD9: 332; ICD10: G20]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Spasm [ICD9: 728.85; ICD10: R25.2]
Schizophrenia [ICD9: 295; ICD10: F20]
Seizures [ICD9: 345.9, 780.3; ICD10: G40, P90, R56]
Seizures occurring during or following neurosurgery [ICD10: G40]
Seizures associated with lennox-Gastaut syndrome [ICD10: R56.9]
Type 1 diabetes [ICD9: 250; ICD10: E10]
Urea cycle disorders [ICD9: 270.6; ICD10: E72.2]
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
BioChemical Class
Sodium channel
Target Validation
T29303
UniProt ID
P35498
Sequence
MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKN
LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKI
AIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCL
EDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNY
NGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNY
GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA
VVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLS
DSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEG
NRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFED
NESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVP
TSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASIL
TNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVL
NTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV
TLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII
VFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM
EVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMH
KGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVN
GTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEE
SKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGR
GKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFT
YIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA
LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTT
TGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYA
AVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM
TEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMV
ETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMF
LAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV
MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPD
CDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPL
SEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGD
RIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAV
IIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTA
ACPPSYDRVTKPIVEKHEQEGKDEKAKGK
Drugs and Mode of Action
Drug(s) Benzocaine Drug Info Approved Anesthesia [534892]
Butacaine Drug Info Approved Pain [551871]
Carbamazepine Drug Info Approved Epilepsy [528598], [540778]
Eslicarbazepine Drug Info Approved Seizures [532651], [542371]
Levobupivacaine Drug Info Approved Anesthesia [538559], [542226]
LIDOFLAZINE Drug Info Approved Angina pectoris [551871]
LOMERIZINE Drug Info Approved Migraine [545070], [551871]
Mepivacaine Drug Info Approved Local or regional analgesia and anesthesia [551871]
Oxybuprocaine Drug Info Approved Anesthesia [542131], [550739]
Pachycarpine Drug Info Approved Oxytocic [551871]
Permethrin Drug Info Approved Infections with sarcoptes scabiei [538286], [551871]
Phenacemide Drug Info Approved Epilepsy [538401], [542284]
Phenytoin Drug Info Approved Seizures occurring during or following neurosurgery [551871]
Pilsicainide Drug Info Approved Heart arrhythmia [551871]
Pirmenol Drug Info Approved Heart arrhythmia [551871]
Rufinamide Drug Info Approved Seizures associated with lennox-Gastaut syndrome [529941], [542495], [551871]
Zonisamide Drug Info Approved Epilepsy [536756], [542058]
Rufinamide Drug Info Approved (orphan drug) Epilepsy [536845], [542495]
I.V. carbamazepine Drug Info NDA filed Type 1 diabetes [551104]
Carisbamate Drug Info Phase 3 Epilepsy; Focal; Seizure disorder [536934]
Intravenous carbamazepine Drug Info Phase 3 Gastric cancer [523052]
Ralfinamide Drug Info Phase 3 Neuropathic pain [536374]
BN82451 Drug Info Phase 2 Parkinson's disease [524900]
COL-1077 Drug Info Phase 2 Pain [525222]
CROBENETINE HYDROCHLORIDE Drug Info Phase 2 Pain [524933]
GSK1014802 Drug Info Phase 2 Bipolar disorder [548689]
GSK2339345 Drug Info Phase 2 Cough [524368]
NS-7 Drug Info Phase 2 Nerve injury [525754]
Phenylbutyrate Drug Info Phase 2 Urea cycle disorders [536447], [543164]
SMP-986 Drug Info Phase 2 Overactive bladder disorder [548182]
TV-45070 Drug Info Phase 2 Osteoarthritis [524653]
P-552-02 Drug Info Phase 1/2 Cystic fibrosis [467618], [523506]
ADCI Drug Info Phase 1 Epileptic seizures [525718]
AZD-3161 Drug Info Phase 1 Peripheral neuropathy [549173]
BDD-10103 Drug Info Phase 1 Pain [550380]
NW-3509 Drug Info Phase 1 Schizophrenia [548597]
LUBELUZOLE Drug Info Discontinued in Preregistration Neurological disease [545928]
Bidisomide Drug Info Discontinued in Phase 3 Heart arrhythmia [544572]
Licarbazepine Drug Info Discontinued in Phase 3 Bipolar disorder [536295]
4030W92 Drug Info Discontinued in Phase 2 Pain [546124]
4991W93 Drug Info Discontinued in Phase 2 Migraine [546577]
534U87 Drug Info Discontinued in Phase 2 Epileptic seizures [546089]
Levosemotiadil Drug Info Discontinued in Phase 2 Cardiac arrhythmias [545959]
Org-7797 Drug Info Discontinued in Phase 2 Cardiac arrhythmias [544606]
Pentisomide Drug Info Discontinued in Phase 2 Heart arrhythmia [544603]
Pyrazinoylguanidine Drug Info Discontinued in Phase 2 Diabetes [545139]
RSD-921 Drug Info Discontinued in Phase 2 Anesthesia [546121]
SILPERISONE HYDROCHLORIDE Drug Info Discontinued in Phase 2 Spasm [545273]
SIPATRIGINE Drug Info Discontinued in Phase 2 Neurological disease [545614]
SOLPECAINOL HYDROCHLORIDE Drug Info Discontinued in Phase 2 Cardiac arrhythmias [545414]
AMELTOLIDE Drug Info Discontinued in Phase 1 Epileptic seizures [546417]
Artilide Drug Info Discontinued in Phase 1 Cardiac arrhythmias [545134]
AWD-140-190 Drug Info Discontinued in Phase 1 Epileptic seizures [545957]
SL-90.0571 Drug Info Discontinued in Phase 1 Epilepsy [545133]
A-76895 Drug Info Terminated Epilepsy [545130]
AM-66 Drug Info Terminated Pain [547806]
BDF-9148 Drug Info Terminated Cardiac failure [546482]
Berlafenone Drug Info Terminated Heart arrhythmia [544579]
BW-1003C87 Drug Info Terminated Cerebrovascular ischaemia [545299]
DPI-201-106 Drug Info Terminated Cardiovascular disorder [544559]
E-2070 Drug Info Terminated Neuropathic pain [547856]
GE-68 Drug Info Terminated Heart arrhythmia [544938]
PD-85639 Drug Info Terminated Discovery agent [545294]
R-59494 Drug Info Terminated Ischemia [545149]
Ralitoline Drug Info Terminated Epilepsy [545466]
Recainam Drug Info Terminated Heart arrhythmia [544594]
RP-66055 Drug Info Terminated Cerebral infarction [545484]
RS-2135 Drug Info Terminated Heart arrhythmia [544815]
SRSC-355 Drug Info Terminated Neuropathic pain [547656]
U-54494A Drug Info Terminated Epilepsy [545129]
U-92032 Drug Info Terminated Discovery agent [545700]
Inhibitor 2-(1-Pentyl-hexyl)-4-phenyl-1H-imidazole Drug Info [527102]
2-Hexyl-4-(4-isobutyl-phenyl)-1H-imidazole Drug Info [527102]
2-Hydroxy-2-phenyl-nonanoic acid amide Drug Info [525483]
4-Biphenyl-4-yl-2-(1-pentyl-hexyl)-1H-imidazole Drug Info [527102]
4-Biphenyl-4-yl-2-(1-propyl-butyl)-1H-imidazole Drug Info [527102]
4-Biphenyl-4-yl-2-cyclohexylmethyl-1H-imidazole Drug Info [527102]
4-Biphenyl-4-yl-2-hexyl-1H-imidazole Drug Info [527102]
4-Biphenyl-4-yl-2-methyl-1H-imidazole Drug Info [527102]
5-Ethyl-3-methyl-5-phenyl-oxazolidine-2,4-dione Drug Info [533048]
5-Heptyl-5-phenyl-imidazolidine-2,4-dione Drug Info [525483]
5-Hexyl-5-phenyl-imidazolidine-2,4-dione Drug Info [525483]
5-Nonyl-5-phenyl-imidazolidine-2,4-dione Drug Info [525483]
BW-202W92 Drug Info [530055]
Indol-1-yl-propyl-pyridin-4-yl-amine Drug Info [525961]
L-741742 Drug Info [525540]
LIDOFLAZINE Drug Info [533974]
LOMERIZINE Drug Info [525961]
LUBELUZOLE Drug Info [525961]
PD-85639 Drug Info [525961]
SIPATRIGINE Drug Info [525961]
TV-45070 Drug Info [551782]
U-92032 Drug Info [525864]
Modulator 4030W92 Drug Info [527123], [551871]
4991W93 Drug Info [531151]
534U87 Drug Info [525627]
A-76895 Drug Info [550851]
ADCI Drug Info [525718]
AMELTOLIDE Drug Info [530733], [551871]
Artilide Drug Info [550029], [551871]
AWD-140-190 Drug Info [534534]
AZD-3161 Drug Info [551649]
BDD-10103 Drug Info [550379]
BDF-9148 Drug Info [534586]
Berlafenone Drug Info [550935]
Bidisomide Drug Info [527361]
Butacaine Drug Info [550133], [551871]
BW-1003C87 Drug Info [533793]
Carbamazepine Drug Info [532579]
DPI-201-106 Drug Info [531461]
GE-68 Drug Info [534330]
GSK2339345 Drug Info [523738]
I.V. carbamazepine Drug Info [532579]
Intravenous carbamazepine Drug Info [532579]
Levosemotiadil Drug Info [525617]
NS-7 Drug Info [525754]
Org-7797 Drug Info [532751]
Pachycarpine Drug Info [527072], [533488]
Pentisomide Drug Info [534070]
Pilsicainide Drug Info [531607], [551871]
Pirmenol Drug Info [531502], [551871]
Pyrazinoylguanidine Drug Info [528291]
R-59494 Drug Info [526753]
Ralitoline Drug Info [526758]
Recainam Drug Info [533728]
RP-66055 Drug Info [533787]
RS-2135 Drug Info [526657]
RSD-921 Drug Info [525513]
SILPERISONE HYDROCHLORIDE Drug Info [527704], [551871]
SL-90.0571 Drug Info [550935]
SOLPECAINOL HYDROCHLORIDE Drug Info [550841], [551871]
SRSC-355 Drug Info [550165]
U-54494A Drug Info [533350]
Blocker AM-66 Drug Info [550851]
Benzocaine Drug Info [536525]
BN82451 Drug Info [537349]
Carisbamate Drug Info [536498], [536845], [536934]
E-2070 Drug Info [536056]
Eslicarbazepine Drug Info [536934]
GSK1014802 Drug Info [550963]
Levobupivacaine Drug Info [535077]
Licarbazepine Drug Info [536295]
Mepivacaine Drug Info [535077]
NW-3509 Drug Info [551426]
Oxybuprocaine Drug Info [537300]
P-552-02 Drug Info [551923]
Permethrin Drug Info [535876]
Phenacemide Drug Info [536316]
Phenylbutyrate Drug Info [536447]
Phenytoin Drug Info [537516]
Ralfinamide Drug Info [536374]
Rufinamide Drug Info [536498]
Saxitoxin Drug Info [538049]
Zonisamide Drug Info [536848]
Antagonist COL-1077 Drug Info [549800]
CROBENETINE HYDROCHLORIDE Drug Info [526220], [551871]
SMP-986 Drug Info [551635]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 467618(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4280).
Ref 523052ClinicalTrials.gov (NCT01128959) Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy. U.S. National Institutes of Health.
Ref 523506ClinicalTrials.gov (NCT01369589) An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness. U.S. National Institutes of Health.
Ref 524368ClinicalTrials.gov (NCT01899768) GSK2339345 Hypertussive Challenge Study. U.S. National Institutes of Health.
Ref 524653ClinicalTrials.gov (NCT02068599) A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee. U.S. National Institutes of Health.
Ref 524900ClinicalTrials.gov (NCT02231580) Study Exploring Safety, Pharmacokinetic and Pharmacodynamic of BN82451 in Male Huntington's Disease Patients. U.S. National Institutes of Health.
Ref 524933ClinicalTrials.gov (NCT02251197) Safety and Tolerability of BIII 890 in Patients With Acute Ischemic Stroke. U.S. National Institutes of Health.
Ref 525222ClinicalTrials.gov (NCT02465320) COL-1077 (Lidocaine Bioadhesive Gel, 10%) in Women Undergoing Transvaginal Pipelle-Directed Endometrial Biopsy.
Ref 525718The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine. Epilepsia. 2000 Mar;41(3):263-70.
Ref 525754Preferential inhibition by a novel Na(+)/Ca(2+) channel blocker NS-7 of severe to mild hypoxic injury in rat cerebrocortical slices: A possible involvement of a highly voltage-dependent blockade of Ca(2+) channel. J Pharmacol Exp Ther. 2000 May;293(2):522-9.
Ref 528598Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice. CNS Drugs. 2007;21(1):47-71.
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.
Ref 534892Double-blind, randomized, placebo-controlled clinical trials with non-prescription medications for the treatment of obesity. Obes Res. 1999 Jul;7(4):370-8.
Ref 536295Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34.
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
Ref 536447Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
Ref 536756Use of second-generation antiepileptic drugs in the pediatric population. Paediatr Drugs. 2008;10(4):217-54.
Ref 536845Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39.
Ref 536934Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. Epub 2008 Nov 12.
Ref 538286FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074806.
Ref 538401FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 007707.
Ref 538559FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020997.
Ref 540778(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5339).
Ref 542058(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7047).
Ref 542131(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7123).
Ref 542226(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7211).
Ref 542284(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7265).
Ref 542371(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7350).
Ref 542495(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7470).
Ref 543164(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8480).
Ref 544559Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000134)
Ref 544572Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000174)
Ref 544579Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000213)
Ref 544594Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000248)
Ref 544603Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000271)
Ref 544606Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000279)
Ref 544815Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001212)
Ref 544938Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001596)
Ref 545070Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002033)
Ref 545129Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002236)
Ref 545130Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002237)
Ref 545133Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002249)
Ref 545134Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002256)
Ref 545139Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002279)
Ref 545149Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002300)
Ref 545273Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002660)
Ref 545294Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002730)
Ref 545299Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002740)
Ref 545414Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003158)
Ref 545466Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003367)
Ref 545484Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003439)
Ref 545614Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003904)
Ref 545700Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004258)
Ref 545928Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005388)
Ref 545957Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005495)
Ref 545959Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005516)
Ref 546089Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006296)
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