Target Information

Target General Infomation
Target ID
T25889
Former ID
TTDR00979
Target Name
Adenylate cyclase
Synonyms
ATP pyrophosphate-lyase; Adenylyl cyclase
Target Type
Discontinued
Disease Cardiac failure [ICD10: I50]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Function
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp- cAMP, which then induces its own transcription again.
BioChemical Class
Phosphorus-oxygen lyases
Target Validation
T25889
EC Number
EC 4.6.1.1
Drugs and Mode of Action
Drug(s) Ad5-AC6 Drug Info Terminated Cardiac failure [547116]
Inhibitor 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE Drug Info [551374]
2,5-didesoxy-3-ATP Drug Info [529597]
2-hydroxy-17beta-estradiol Drug Info [529597]
Adenosine-5'-Rp-Alpha-Thio-Triphosphate Drug Info [551391]
Alpha,Beta-Methyleneadenosine-5'-Triphosphate Drug Info [551393]
Cyclic Adenosine Monophosphate Drug Info [551393]
DEOXYADENOSINE Drug Info [526967]
N6-CYCLOPENTYLADENOSINE Drug Info [528965]
NSC-270718 Drug Info [529597]
NSC-88915 Drug Info [529597]
Modulator Ad5-AC6 Drug Info [544174]
References
Ref 547116Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013170)
Ref 526967J Med Chem. 2004 Feb 26;47(5):1207-13.Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase.
Ref 528965J Med Chem. 1991 Dec;34(12):3388-90.Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
Ref 529597J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors.
Ref 544174Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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