Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX1GAI
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| Drug Name |
(1S,2R,3R)-1-(7-Fluoro-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid
|
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| Synonyms |
CHEMBL1767012
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C22H22FN3O4S
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| Canonical SMILES |
C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)N3CCc4c(C3)[nH]c5cc(F)ccc45)C(=O)O
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| InChI |
InChI=1S/C22H22FN3O4S/c1-13-20(14-5-3-2-4-6-14)22(13,21(27)28)25-31(29,30)26-10-9-17-16-8-7-15(23)11-18(16)24-19(17)12-26/h2-8,11,13,20,24-25H,9-10,12H2,1H3,(H,27,28)/t13-,20-,22+/m1/s1
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| InChIKey |
VFXFWORULVVRDM-YIKPVDIZSA-N
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| Target and Pathway | |||||
| Target(s) | Interstitial collagenase | Target Info | [1587926] | ||
| Matrix metalloproteinase-14 | Target Info | [1587926] | |||
| Pathway Interaction Database | Endothelins | ||||
| Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |||||
| Glucocorticoid receptor regulatory network | |||||
| AP-1 transcription factor network | |||||
| Syndecan-1-mediated signaling eventshif2pathway:HIF-2-alpha transcription factor network | |||||
| Signaling events mediated by focal adhesion kinase | |||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Bladder Cancer | |||||
| Activation of Matrix Metalloproteinases | |||||
| Degradation of collagen | |||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
| Oncostatin M Signaling Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell surface interactions at the vascular wall | |||||
| Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer | |||||
| AGE/RAGE pathway | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
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