Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX5LXF
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| Drug Name |
4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-[3-(3,4,5-trifluorophenoxyacetamido)phenoxy]pyrimidine
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| Synonyms |
CHEMBL1928959
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C31H21ClF4N4O4
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| Canonical SMILES |
Fc1cccc(COc2ccc(Nc3cc(Oc4cccc(NC(=O)COc5cc(F)c(F)c(F)c5)c4)ncn3)cc2Cl)c1
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| InChI |
InChI=1S/C31H21ClF4N4O4/c32-24-11-21(7-8-27(24)43-15-18-3-1-4-19(33)9-18)39-28-14-30(38-17-37-28)44-22-6-2-5-20(10-22)40-29(41)16-42-23-12-25(34)31(36)26(35)13-23/h1-14,17H,15-16H2,(H,40,41)(H,37,38,39)
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| InChIKey |
GMHCEPVFLSLCMH-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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