Drug Information

Drug General Information
Drug ID
DXL7LD
Drug Name
N-[5-(2-Fluoro-phenyl)-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-2-(3-methoxy-phenyl)-acetamide: 0.16CH2Cl2
Synonyms
CHEMBL1907666
Indication Discovery agent Investigative [1587926]
Formula
C25H22FN3O3
Canonical SMILES
COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c4ccccc4N(C)C2=O)c1
InChI
InChI=1S/C25H22FN3O3/c1-29-21-13-6-4-11-19(21)23(18-10-3-5-12-20(18)26)28-24(25(29)31)27-22(30)15-16-8-7-9-17(14-16)32-2/h3-14,24H,15H2,1-2H3,(H,27,30)/t24-/m0/s1
InChIKey
OROBBIIDFVAOPI-DEOSSOPVSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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