Drug Information

Drug General Information
Drug ID
D03FPQ
Former ID
DIB020742
Drug Name
PNU-120596
Synonyms
PNU-120,596
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540607]
Structure
Download
2D MOL
Formula
C13H14ClN3O4
InChI
InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChIKey
CEIIEALEIHQDBX-UHFFFAOYSA-N
PubChem Compound ID
311434
PubChem Substance ID
129314, 5676359, 8884674, 16573044, 26683821, 37504783, 50112882, 53184950, 103564344, 104537751, 125672889, 126731470, 135278190, 135653844, 135697954, 136349526, 136367657, 136367815, 137143665, 152254628, 152258399, 152344123, 160647236, 160821740, 160853492, 162011602, 162023499, 162038042, 162140168, 162202762, 163091667, 163378951, 163838608, 164043578, 164760646, 170485659, 177748567, 178100817, 184567545, 185998764, 188919979, 204427159, 223386118, 223515015, 223540645, 223705245, 227667037, 242059943, 247094134, 249823770
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Modulator (allosteric modulator) [527539]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 540607(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3991).
Ref 527539A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci. 2005 Apr 27;25(17):4396-405.

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