Drug Information

Drug General Information
Drug ID
D0F4FK
Former ID
DIB020128
Drug Name
KB-R7943
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467568]
Structure
Download
2D MOL
Formula
C17H21N3O6S2
InChI
InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKey
WGIKEBHIKKWJLG-UHFFFAOYSA-N
PubChem Compound ID
9823846
PubChem Substance ID
14782932, 24126784, 26759016, 44859801, 53787240, 53800721, 57373438, 79464357, 91746340, 135698241, 152079652, 152258706, 152344476, 160647542, 160821209, 162022899, 162249106, 163300006, 163374669, 163687832, 172844987, 175612701, 178101049, 184559922, 186014463, 204398567, 206251943, 208264937, 223393652, 227029080, 241182266, 242060122, 252215637, 252316128, 252433933, 252553669
Target and Pathway
Target(s) Short transient receptor potential channel 6 Target Info Blocker (channel blocker) [543855]
TRP cation channel C5 Target Info Blocker (channel blocker) [528962]
Short transient receptor potential channel 3 Target Info Blocker (channel blocker) [543852]
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Endothelins
Nephrin/Neph1 signaling in the kidney podocyte
EPO signaling pathway
PAR1-mediated thrombin signaling eventspi3kplctrkpathway:Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome Effects of PIP2 hydrolysis
TRP channels
Role of second messengers in netrin-1 signalingR-HSA-3295583:TRP channels
Role of second messengers in netrin-1 signalingR-HSA-114508:Effects of PIP2 hydrolysis
Role of second messengers in netrin-1 signaling
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
Platelet homeostasis
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysisWP1868:Netrin-1 signalingWP1885:Platelet homeostasis
Effects of PIP2 hydrolysis
References
Ref 467568(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4232).
Ref 528962The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun. 2007 Sep 14;361(1):230-6. Epub 2007 Jul 16.
Ref 543852(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
Ref 543855(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491).

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