Drug Information

Drug General Information
Drug ID
D0Y9SE
Former ID
DIB020147
Drug Name
KT 5823
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540328]
Structure
Download
2D MOL
Formula
C29H25N3O5
InChI
InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
InChIKey
QTYMDECKVKSGSM-YMUMJAELSA-N
PubChem Compound ID
108152
PubChem Substance ID
14859710, 24896206, 44437038, 50064300, 50381659, 53789795, 135065112, 135652699, 135698757, 162249828, 164811461, 198964857, 241020663, 248185526, 249807087
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [525801]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540328(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 338).
Ref 525801Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Mol Pharmacol. 2000 Jul;58(1):194-207.

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