Drug Information

Drug General Information
Drug ID
D0VU7U
Former ID
DCL000606
Drug Name
R3487
Drug Type
Small molecular drug
Indication Alzheimer disease; Schizophrenia [ICD9: 295, 331.0; ICD10:F20, G30] Phase 2 [530352]
Company
Roche
Structure
Download
2D MOL

3D MOL
Formula
Na
Canonical SMILES
[Na]
InChI
1S/Na
InChIKey
KEAYESYHFKHZAL-UHFFFAOYSA-N
PubChem Compound ID
5360545
PubChem Substance ID
5326610, 8146756, 10534514, 15170295, 15237733, 24845275, 24848128, 24853383, 24854694, 24855921, 24857014, 24857016, 24868737, 24871915, 24881721, 24886151, 24886235, 24888697, 33088985, 39384005, 50046431, 50074094, 53788965, 57362018, 57647078, 57648086, 57652275, 57652326, 77905220, 83620210, 88826695, 114148349, 117376386, 125809647, 126675963, 131325865, 134339053, 134339153, 134339154, 134339155, 134339359, 134339385, 134339536, 134339884, 134340144, 134987874, 134988506, 137102243, 137156482, 139072878
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Agonist [551607]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 530352Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov. 2009 Sep;8(9):733-50.
Ref 551607Clinical pipeline report, company report or official report of Roche (2009).

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