Drug General Information
Drug ID
D0M2MR
Former ID
DAP000522
Drug Name
Gliclazide
Synonyms
Diaikron; Diamicron; Gliclazida; Gliclazidum; Gliklazid; Glimicron; Glyclazide; Nordialex; S 1702; S 852; SE 1702; Diamicron (TN); Dianorm (TN); Gliclazida [INN-Spanish]; Gliclazidum [INN-Latin]; Glimicron (TN); S-1702; S-852; Gliclazide (JAN/INN); Glubitor-OD (TN); Gliclazide [BAN:INN:DCF:JAN]; N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide; N-[(hexahydrocyclopenta[c]pyrrol-2(1H)-ylamino)carbonyl]-4-methylbenzenesulfonamide; N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea; 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea; 1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea; 1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea; 1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Approved [549819]
Therapeutic Class
Hypoglycemic Agents
Structure
Download
2D MOL

3D MOL

Formula
C15H21N3O3S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
InChI
1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
InChIKey
BOVGTQGAOIONJV-UHFFFAOYSA-N
CAS Number
CAS 21187-98-4
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:31654
SuperDrug ATC ID
A10BB09
SuperDrug CAS ID
cas=021187984
Target and Pathway
Target(s) Sulfonylurea receptor 1 Target Info Blocker [535269], [535457]
KEGG Pathway ABC transporters
Insulin secretion
Type II diabetes mellitus
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
PathWhiz Pathway Muscle/Heart Contraction
Pancreas Function
Reactome ABC-family proteins mediated transport
Regulation of insulin secretion
WikiPathways Potassium Channels
Integration of energy metabolism
References
Ref 549819Cefradine - FDA approved drug information (drug label) from DailyMed.
Ref 535269Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9.
Ref 535457Pharmacological modulation of K(ATP) channels. Biochem Soc Trans. 2002 Apr;30(2):333-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.