Drug General Information
Drug ID
D0E3WH
Former ID
DNC006855
Drug Name
2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528311]
Structure
Download
2D MOL

3D MOL

Formula
C16H15NO
Canonical SMILES
CC1=CC=C(C=C1)OCC#CC2=NC(=CC=C2)C
InChI
1S/C16H15NO/c1-13-8-10-16(11-9-13)18-12-4-7-15-6-3-5-14(2)17-15/h3,5-6,8-11H,12H2,1-2H3
InChIKey
GMIZGDGVYPBQCS-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528311]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528311Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. Epub 2006 Jul 12.A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Ref 528311Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. Epub 2006 Jul 12.A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).

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