Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0JV2P
|
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| Former ID |
DIB019031
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| Drug Name |
BTP2
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| Synonyms |
YM-58483
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [539566] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C15H9F6N5OS
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| InChI |
InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
|
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| InChIKey |
XPRZIORDEVHURQ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3164889, 5597343, 8151638, 11394760, 12054562, 14807025, 26536396, 26758342, 29221619, 48334613, 50735545, 92272042, 103317256, 104300638, 123220366, 124652464, 125333805, 129723246, 135650028, 139426324, 162249921, 163124766, 163688491, 172890466, 204377153, 226971520, 241053694, 241376719, 252157654, 252450579, 252457328
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| Target and Pathway | |||||
| Target(s) | Short transient receptor potential channel 3 | Target Info | Blocker (channel blocker) | [527376] | |
| TRPM4 | Target Info | Activator | [527963] | ||
| TRP cation channel C5 | Target Info | Blocker (channel blocker) | [543854] | ||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| References | |||||
| Ref 527376 | A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006. Epub 2005 Jan 12. | ||||
| Ref 527963 | A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. Mol Pharmacol. 2006 Apr;69(4):1413-20. Epub 2006 Jan 11. | ||||
| Ref 543854 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490). | ||||
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