Drug General Information
Drug ID
D0BB0O
Former ID
DIB018560
Drug Name
2MeSADP
Synonyms
2-methylthio-ADP; 2-MeSADP; 2-methylthio-adenosine-5'-diphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539063]
Structure
Download
2D MOL
Formula
C11H17N5O10P2S
InChI
InChI=1S/C11H17N5O10P2S/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
InChIKey
WLMZTKAZJUWXCB-KQYNXXCUSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Agonist [527109]
P2Y purinoceptor 1 Target Info Agonist [526444]
P2Y13 receptor Target Info Agonist [526649]
KEGG Pathway Platelet activationhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome P2Y receptors
G alpha (i) signalling eventsR-HSA-416476:G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 539063(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1710).
Ref 526444Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57.
Ref 526649Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.
Ref 527109P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22.

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