Drug Information

Drug General Information
Drug ID
D08BLV
Former ID
DNC012915
Drug Name
Isopropyl 3-(phenylthio)-1H-indole-2-carboxylate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527999]
Structure
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2D MOL

3D MOL
Formula
C18H17NO2S
Canonical SMILES
CC(C)OC(=O)C1=C(C2=CC=CC=C2N1)SC3=CC=CC=C3
InChI
1S/C18H17NO2S/c1-12(2)21-18(20)16-17(22-13-8-4-3-5-9-13)14-10-6-7-11-15(14)19-16/h3-12,19H,1-2H3
InChIKey
CIEJDDRWESEPGF-UHFFFAOYSA-N
PubChem Compound ID
11630982
Target and Pathway
Target(s) Tubulin Target Info Inhibitor [527999]
Tubulin beta Target Info Inhibitor [527999]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 527999J Med Chem. 2006 Feb 9;49(3):947-54.New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.
Ref 527999J Med Chem. 2006 Feb 9;49(3):947-54.New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.

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