Drug Information

Drug General Information
Drug ID
D03FNQ
Former ID
DNC006952
Drug Name
ADS-103214
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528581]
Structure
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2D MOL

3D MOL
Formula
C21H21F3N4O2
Canonical SMILES
CN1C2=C(C=CC(=C2)NC(=O)COC3=CC=C(C=C3)C(F)(F)F)N=C1N4CC<br />CC4
InChI
1S/C21H21F3N4O2/c1-27-18-12-15(6-9-17(18)26-20(27)28-10-2-3-11-28)25-19(29)13-30-16-7-4-14(5-8-16)21(22,23)24/h4-9,12H,2-3,10-11,13H2,1H3,(H,25,29)
InChIKey
BHTNQFXUFJJYNG-UHFFFAOYSA-N
PubChem Compound ID
11281523
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Inhibitor [528581]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.
Ref 528581Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. Epub 2006 Dec 2.Quinazoline and benzimidazole MCH-1R antagonists.

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