Drug Information

Drug General Information
Drug ID
D0YG0D
Former ID
DNC011196
Drug Name
1'-tosylspiro[indene-1,4'-piperidine]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530975]
Structure
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2D MOL

3D MOL
Formula
C20H21NO2S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2CCC3(CC2)C=CC4=CC=CC=C34
InChI
1S/C20H21NO2S/c1-16-6-8-18(9-7-16)24(22,23)21-14-12-20(13-15-21)11-10-17-4-2-3-5-19(17)20/h2-11H,12-15H2,1H3
InChIKey
VRVIZJNFYYAUKC-UHFFFAOYSA-N
PubChem Compound ID
9797987
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Inhibitor [530975]
Oxytocin receptor Target Info Inhibitor [530975]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contractionhsa04020:Calcium signaling pathway
cAMP signaling pathway
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
GPCR downstream signaling
References
Ref 530975J Med Chem. 2010 Sep 23;53(18):6525-38.Oral oxytocin antagonists.
Ref 530975J Med Chem. 2010 Sep 23;53(18):6525-38.Oral oxytocin antagonists.

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