Drug Information

Drug General Information
Drug ID
D0F4NS
Former ID
DNC004616
Drug Name
Mozavaptan
Drug Type
Small molecular drug
Indication Hyponatraemia [ICD10:E87.1] Approved [539396], [544970], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C27H29N3O2
InChI
InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
InChIKey
WRNXUQJJCIZICJ-UHFFFAOYSA-N
CAS Number
CAS 137975-06-5
PubChem Compound ID
119369
PubChem Substance ID
7980203, 10238465, 14929794, 29300265, 49876628, 50784549, 57339461, 85210057, 85856507, 92251402, 92720235, 103283744, 103938054, 104408167, 118843944, 125340574, 126522418, 126584454, 126620153, 126667663, 129623867, 131298331, 134341821, 135075013, 135650774, 137249480, 142385824, 152035180, 162009841, 162011504, 164826782, 170466304, 172914187, 174527391, 179149887, 206246079, 211535800, 223434818, 223658567, 225355504, 227838631, 241033722, 242059895, 252215844, 252472557
Target and Pathway
Target(s) Vasopressin V1b receptor Target Info Inhibitor [533576]
Vasopressin V2 receptor Target Info Inhibitor [533576]
Vasopressin V1a receptor Target Info Inhibitor [533576]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contractionhsa04080:Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway
Vascular smooth muscle contraction
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
GPCR downstream signaling
References
Ref 539396(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2197).
Ref 544970Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001739)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 533576J Med Chem. 1981 May;24(5):496-9.New analgesic drugs derived from phencyclidine.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.