Drug Information

Drug General Information
Drug ID
D01HCL
Former ID
DIB018475
Drug Name
13,14-dihydro-PGE1
Synonyms
13,14-dihydro-prostaglandin E1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539246]
Structure
Download
2D MOL
Formula
C20H36O5
InChI
InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h15-17,19,21,23H,2-14H2,1H3,(H,24,25)/t15-,16+,17+,19+/m0/s1
InChIKey
DPOINJQWXDTOSF-DODZYUBVSA-N
PubChem Compound ID
161273
PubChem Substance ID
4266060, 10254406, 11120196, 11120684, 11121172, 11121394, 11121874, 11147279, 11362463, 11365025, 11367587, 11370197, 11370198, 11373188, 11375749, 26754838, 26754839, 46236146, 47440002, 47440003, 50110798, 57278192, 57349451, 77504584, 92309745, 99300659, 99302177, 103097584, 103097585, 104046456, 113446651, 126524627, 127768583, 131342665, 134224789, 135116858, 135651374, 142826069, 179205586, 231313899, 242279203, 251966034, 252455469, 252457185, 252464034
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [525852]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539246(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1946).
Ref 525852Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. Br J Pharmacol. 2000 Aug;130(8):1919-26.

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