Drug General Information
Drug ID	D0R0JE
Former ID	DNC007534
Drug Name	3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528893]
Structure		Download 2D MOL 3D MOL
Formula	C12H8BrN3
Canonical SMILES	CC1=CN=NC(=N1)C#CC2=CC(=CC=C2)Br
InChI	1S/C12H8BrN3/c1-9-8-14-16-12(15-9)6-5-10-3-2-4-11(13)7-10/h2-4,7-8H,1H3
InChIKey	ZFPUZPDBHDTJCE-UHFFFAOYSA-N
PubChem Compound ID	16735841
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[528893]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528893	J Med Chem. 2007 Jul 12;50(14):3388-91. Epub 2007 Jun 15.Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Ref 528893	J Med Chem. 2007 Jul 12;50(14):3388-91. Epub 2007 Jun 15.Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.

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