Drug Information

Drug General Information
Drug ID
D0Y6LS
Former ID
DIB019062
Drug Name
carbocyclic thromboxane A2
Synonyms
9alpha,11alpha,11a-dicarba-TXA2; CTA-2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539267]
Structure
Download
2D MOL
Formula
C22H36O3
InChI
InChI=1S/C22H36O3/c1-2-3-6-9-20(23)13-12-18-14-17-15-19(16-17)21(18)10-7-4-5-8-11-22(24)25/h4,7,12-13,17-21,23H,2-3,5-6,8-11,14-16H2,1H3,(H,24,25)/b7-4-,13-12+/t17?,18-,19?,20-,21+/m0/s1
InChIKey
ZIWNJZLXPXFNGN-GXTQQWMXSA-N
PubChem Compound ID
5311387
PubChem Substance ID
7980456, 16280612, 39341067, 57359462, 78729476, 114155965, 135650139, 139047658, 142211411, 142636306, 172113672, 198938334, 250134072
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Agonist [526825]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539267(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1970).
Ref 526825Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets. Jpn J Pharmacol. 1992 Jul;59(3):357-64.

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