TTD | Drug: D0G2XM

Drug General Information
Drug ID	D0G2XM
Former ID	DNC004153
Drug Name	AP-227
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[545879]
Structure		Download 2D MOL 3D MOL
Formula	C30H33NO4
Canonical SMILES	CCCC(=NOC(C1=CC=CC=C1)C2=CC=CC=C2)CC3CCC4=C(C3)C=CC=C4O<br />CC(=O)O
InChI	1S/C30H33NO4/c1-2-10-26(31-35-30(23-11-5-3-6-12-23)24-13-7-4-8-14-24)20-22-17-18-27-25(19-22)15-9-16-28(27)34-21-29(32)33/h3-9,11-16,22,30H,2,10,17-21H2,1H3,(H,32,33)/b31-26+
InChIKey	XNRBBSJYERPMMB-GKPLWNPISA-N
PubChem Compound ID	9847589
Target and Pathway
Target(s)	Prostacyclin receptor	Target Info	Inhibitor	[551275]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Platelet activation
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome	Prostanoid ligand receptors
Reactome	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	Endothelin Pathways
	Platelet homeostasis
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545879	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005184)
Ref 551275	Molecular design of novel PGI2 agonists without PG skeleton, Bioorg. Med. Chem. Lett. 5(10):1071-1076 (1995).

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Drug Information