Drug Information

Drug General Information
Drug ID
D0N1TQ
Former ID
DIB019824
Drug Name
ER819762
Synonyms
ER-819762; ER 819762
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540642]
Structure
Download
2D MOL
Formula
C30H39N3O3
InChI
InChI=1S/C30H39N3O3/c1-7-33-29(34)32-19-24-16-25(35-5)17-26(36-6)28(24)22(4)15-27(32)30(33)8-10-31(11-9-30)18-23-13-20(2)12-21(3)14-23/h12-17,22H,7-11,18-19H2,1-6H3/t22-/m0/s1
InChIKey
ANKFBAJRCGOKJJ-QFIPXVFZSA-N
PubChem Compound ID
42596951
PubChem Substance ID
74368683, 86439916, 137764954, 178100864, 237817270, 247248021
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Antagonist [530872]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540642(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4040).
Ref 530872A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol. 2010 May;160(2):292-310.

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