Drug Information

Drug General Information
Drug ID
D0XO2G
Former ID
DIB018832
Drug Name
AMG 9810
Synonyms
AMG-9810; AMG9810
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541491]
Structure
Download
2D MOL
Formula
C21H23NO3
InChI
InChI=1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
InChIKey
GZTFUVZVLYUPRG-IZZDOVSWSA-N
PubChem Compound ID
680502
PubChem Substance ID
882814, 3549920, 9283109, 16439871, 25818630, 26753279, 44865144, 49688584, 50075744, 53790930, 57408530, 76105963, 89282702, 90341516, 103464558, 108413549, 109869769, 121361842, 135332129, 135698247, 137757200, 162248063, 163565172, 164106815, 164760662, 175612731, 177748553, 178102965, 179721459, 187072159, 198981904, 202824628, 204380356, 223455460, 229139810, 229139821, 241104828, 252156440, 252366026
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Blocker (channel blocker) [527355]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 541491(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6347).
Ref 527355AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther. 2005 Apr;313(1):474-84. Epub 2004 Dec 22.

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