Drug Information

Drug General Information
Drug ID
D0M3KZ
Former ID
DIB020482
Drug Name
NAD
Synonyms
NAD+
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539580]
Structure
Download
2D MOL
Formula
C21H27N7O14P2
InChI
InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChIKey
BAWFJGJZGIEFAR-NNYOXOHSSA-N
PubChem Compound ID
5892
PubChem Substance ID
841105, 7836298, 7885587, 7889144, 7889277, 8149434, 8153645, 14790299, 14912780, 26611829, 26681097, 26697181, 29224919, 49699158, 50033280, 50123523, 50123524, 53787893, 57323025, 57551970, 77064053, 87567516, 91011349, 92298062, 92307336, 99301277, 104250768, 104310545, 121363359, 124637933, 134971502, 135364879, 135651521, 135692504, 137241347, 144075133, 144203872, 152031738, 160810701, 162038182, 162180452, 163088706, 172097172, 179210308, 183213584, 204379330, 210279594, 210281917, 226500313, 250133618
Target and Pathway
Target(s) Long transient receptor potential channel 2 Target Info Activator [526528]
P2Y11 receptor Target Info Agonist [528388]
Reactome TRP channels
References
Ref 539580(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2451).
Ref 526528Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD. Biochem J. 2003 May 1;371(Pt 3):1045-53.
Ref 528388Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J Biol Chem. 2006 Oct 20;281(42):31419-29. Epub 2006 Aug 22.

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