TTD | Drug: D0E4YW

Drug General Information
Drug ID	D0E4YW
Former ID	DIB018880
Drug Name	ARL66096
Synonyms	2-propylthio-betagamma-difluoromethylene ATP; FPL66096; ARL 66096
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540332]
Structure		Download 2D MOL
Formula	C14H22F2N5O12P3S
InChI	InChI=1S/C14H22F2N5O12P3S/c1-2-3-37-13-19-10(17)7-11(20-13)21(5-18-7)12-9(23)8(22)6(32-12)4-31-36(29,30)33-35(27,28)14(15,16)34(24,25)26/h5-6,8-9,12,22-23H,2-4H2,1H3,(H,27,28)(H,29,30)(H2,17,19,20)(H2,24,25,26)/t6-,8-,9-,12-/m1/s1
InChIKey	ZQXUQOHLHUWLSA-WOUKDFQISA-N
PubChem Compound ID	5311009
PubChem Substance ID	7978729, 11056207, 14838737, 39340741, 50905819, 103760445, 114155043, 178100401
Target and Pathway
Target(s)	P2Y purinoceptor 12	Target Info	Antagonist	[533775]
KEGG Pathway	Platelet activation
Reactome	P2Y receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540332	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3384).
Ref 533775	FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br J Pharmacol. 1994 Nov;113(3):1057-63.

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Drug Information