Drug Information

Drug General Information
Drug ID
D0LD9S
Former ID
DNC010766
Drug Name
SPERMINE
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542107], [546483]
Structure
Download
2D MOL

3D MOL
Formula
C10H26N4
InChI
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChIKey
PFNFFQXMRSDOHW-UHFFFAOYSA-N
CAS Number
CAS 71-44-3
PubChem Compound ID
1103
PubChem Substance ID
4012, 140612, 585338, 600883, 826607, 855222, 3134394, 5612034, 7890561, 7980642, 8143356, 8150975, 10317955, 10533682, 11111791, 11113818, 11439632, 11446854, 14748726, 24439454, 24888220, 24899550, 24899594, 26701763, 26701869, 26704188, 26704193, 26704197, 26704245, 26704375, 26704579, 26705140, 26705170, 26705322, 26705370, 26705680, 26706947, 26706956, 26709511, 26710174, 26711528, 26712356, 26712786, 26713080, 26713117, 26713121, 26713142, 26713516, 26713534, 26713537
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [530824]
Carbonic anhydrase Target Info Inhibitor [530998]
Carbonic anhydrase IV Target Info Inhibitor [530998]
NMDA receptor subunit NR1 Target Info Inhibitor [530824]
Carbonic anhydrase IX Target Info Inhibitor [530998]
Carbonic anhydrase VI Target Info Inhibitor [530998]
Carbonic anhydrase XIV Target Info Inhibitor [530998]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa04014:Ras signaling pathway
Huntington's disease
Alcoholismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathwayhif1_tfpathway:HIF-1-alpha transcription factor network
Reactome Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascadeR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Alzheimers DiseaseWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers DiseaseWP2877:Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
References
Ref 542107(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 710).
Ref 546483Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008464)
Ref 530824J Med Chem. 2010 May 13;53(9):3611-7.Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.
Ref 530998J Med Chem. 2010 Aug 12;53(15):5511-22.Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

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