Drug Information

Drug General Information
Drug ID
D00AWM
Former ID
DIB019986
Drug Name
GW803430
Synonyms
GW-803,430; GW 803430
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540637]
Structure
Download
2D MOL

3D MOL
Formula
C25H24ClN3O3S
InChI
InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3
InChIKey
MWULMTACIBZPGN-UHFFFAOYSA-N
PubChem Compound ID
9826520
PubChem Substance ID
14785703, 24128847, 44924652, 49684234, 57373441, 76211521, 103498862, 104098586, 134346327, 139906647, 162221953, 164042035, 172650157, 178100858, 198972475, 223906474, 228758951, 241376885, 244525366, 249618120, 251963099, 252157902, 252160261
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [528336]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 540637(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4033).
Ref 528336The discovery and optimization of pyrimidinone-containing MCH R1 antagonists. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7. Epub 2006 Jul 25.

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