Drug Information

Drug General Information
Drug ID
D0W1FM
Former ID
DNC010184
Drug Name
4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530390]
Structure
Download
2D MOL

3D MOL
Formula
C22H16N4
Canonical SMILES
C1C=NC2=C1C(=CC=C2)NC3=C(C=NC=C3C#N)C=CC4=CC=CC=C4
InChI
1S/C22H16N4/c23-13-18-15-24-14-17(10-9-16-5-2-1-3-6-16)22(18)26-21-8-4-7-20-19(21)11-12-25-20/h1-10,12,14-15H,11H2,(H,24,26)/b10-9+
InChIKey
DNYURFSSJKXPTF-MDZDMXLPSA-N
PubChem Compound ID
45485013
Target and Pathway
Target(s) mRNA of Protein kinase C-theta Target Info Inhibitor [530390]
KEGG Pathway NF-kappa B signaling pathway
Vascular smooth muscle contraction
Tight junction
T cell receptor signaling pathway
Inflammatory mediator regulation of TRP channels
Adipocytokine signaling pathway
Measles
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
T cell activation
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Endothelins
TCR signaling in na&#xef
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Downstream signaling in na&#xef
Reactome Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling events
WikiPathways TCR Signaling Pathway
Calcium Regulation in the Cardiac Cell
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Fc epsilon receptor (FCERI) signaling
Corticotropin-releasing hormone
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
TCR signaling
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysis
Apoptotic execution phase
References
Ref 530390Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Ref 530390Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.

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