Drug Information

Drug General Information
Drug ID
D08JNK
Former ID
DIB019687
Drug Name
d(CH2)5[D-Ile2,Ile4]AVP
Synonyms
beta-mercapto-beta,beta,cyclopentamethylenepropionyl[D-Ile2,Ile4]AVP; d(CH2)5[D-Ile2,Ile4]VP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539414]
Structure
Download
2D MOL
Formula
C49H77N13O10S2
InChI
InChI=1S/C49H77N13O10S2/c1-5-27(3)40(60-39(65)23-30-16-10-11-19-36(30)74)46(70)57-32(22-29-14-8-7-9-15-29)44(68)61-41(28(4)6-2)47(71)58-33(24-37(50)63)43(67)59-34(26-73)48(72)62-21-13-18-35(62)45(69)56-31(17-12-20-54-49(52)53)42(66)55-25-38(51)64/h7-9,14-15,27-28,30-35,40-41,73H,5-6,10-13,16-26H2,1-4H3,(H2,50,63)(H2,51,64)(H,55,66)(H,56,69)(H,57,70)(H,58,71)(H,59,67)(H,60,65)(H,61,68)(H4,52,53,54)/t27-,28+,30?,31-,32-,33-,34-,35-,40-,41+/m0/s1
InChIKey
CNWFVLCMGVAHSD-HAEBMLOOSA-N
PubChem Compound ID
3080966
PubChem Substance ID
36411863, 57354529, 80184531, 111681727, 135227325, 135652091
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [525878]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539414(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2236).
Ref 525878Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463. Kidney Int. 2000 Oct;58(4):1613-22.

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