Drug Information

Drug General Information
Drug ID
D07FVZ
Former ID
DIB019658
Drug Name
CPPHA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538901]
Structure
Download
2D MOL
Formula
C22H15ClN2O4
InChI
InChI=1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
InChIKey
UFOUABRZSDGGAZ-UHFFFAOYSA-N
PubChem Compound ID
9931205
PubChem Substance ID
14904017, 24206498, 53789324, 56310615, 75720754, 103458725, 104043350, 135294390, 135650135, 135697764, 137128993, 137417840, 139383826, 144115854, 162248681, 163772268, 176239000, 208265366, 210275113, 210280752, 215783741, 223556640, 224054058, 225848547, 227995267, 244801557, 252158357, 252160140, 252450658, 252478308
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator (allosteric modulator) [526946]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538901(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1423).
Ref 526946A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J Pharmacol Exp Ther. 2004 May;309(2):568-77. Epub 2004 Jan 27.

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