Drug Information

Drug General Information
Drug ID
D0O2WX
Former ID
DIB018764
Drug Name
AFP-07
Synonyms
AFP07; AFP 07
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539259]
Structure
Download
2D MOL
Formula
C20H30F2O5
InChI
InChI=1S/C20H30F2O5/c1-2-3-4-7-13(23)10-11-14-15(24)12-16-19(14)20(21,22)17(27-16)8-5-6-9-18(25)26/h8,10-11,13-16,19,23-24H,2-7,9,12H2,1H3,(H,25,26)/b11-10+,17-8-/t13-,14-,15+,16-,19+/m0/s1
InChIKey
ILUYAOVLMOPQAI-BFOOZVJSSA-N
PubChem Compound ID
5311226
PubChem Substance ID
7979732, 11056357, 39340934, 75575906, 114155601, 135649901
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [534364]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 539259(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1962).
Ref 5343647,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Prostaglandins. 1997 Feb;53(2):83-90.

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