Drug General Information
Drug ID	D0IW5C
Former ID	DNC014301
Drug Name	3,4'-(1H-1,2,4-triazole-3,5-diyl)dipyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530410]
Structure		Download 2D MOL 3D MOL
Formula	C12H9N5
Canonical SMILES	C1=CC(=CN=C1)C2=NNC(=N2)C3=CC=NC=C3
InChI	1S/C12H9N5/c1-2-10(8-14-5-1)12-15-11(16-17-12)9-3-6-13-7-4-9/h1-8H,(H,15,16,17)
InChIKey	WIHUWTSKKGOEGI-UHFFFAOYSA-N
PubChem Compound ID	918281
Target and Pathway
Target(s)	Xanthine dehydrogenase/oxidase	Target Info	Inhibitor	[530410]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides degradation
	Adenosine nucleotides degradation
	Retinoate biosynthesis II
KEGG Pathway	Purine metabolism
	Caffeine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Peroxisome
PANTHER Pathway	Adenine and hypoxanthine salvage pathway
	Purine metabolism
PathWhiz Pathway	Caffeine Metabolism
	Purine Metabolism
Reactome	Purine catabolism
WikiPathways	Oxidative Stress
	Effects of Nitric Oxide
	Metabolism of nucleotides
	Selenium Micronutrient Network
References
Ref 530410	Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9. Epub 2009 Sep 2.Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected].
Ref 530410	Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9. Epub 2009 Sep 2.Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected].

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