Drug Information

Drug General Information
Drug ID
D0M0VI
Former ID
DIB018998
Drug Name
BODIPY-pirenzepine
Synonyms
BoPz
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543219]
Structure
Download
2D MOL
Formula
C40H43BF2N8O3S
InChI
InChI=1S/C34H33BF2N7O3S/c36-35(37)43-23(9-10-24(43)21-25-11-13-29(44(25)35)30-8-4-20-48-30)12-14-31(45)41-18-16-40(17-19-41)22-32(46)42-28-7-2-1-5-26(28)34(47)39-27-6-3-15-38-33(27)42/h1-8,11,13,15,20-21,23H,9-10,12,14,16-19,22H2,(H,39,47)
InChIKey
QSQBCLKCVCRIFK-UHFFFAOYSA-N
PubChem Compound ID
101244456
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [530147]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 543219(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8604).
Ref 530147Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. J Biol Chem. 2009 Jul 17;284(29):19533-43.

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