Drug Information

Drug General Information
Drug ID
D05WHD
Former ID
DNC000661
Drug Name
FR161282
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535608]
Structure
Download
2D MOL

3D MOL
Formula
C37H37N5O4
Canonical SMILES
CC1=CC=C(C=C1)C2=CC=CC=C2C(=O)NC3=CC=C(C=C3)C(=O)N4CCC(<br />=O)N(C5=CC=CC=C54)CC(=O)N6CCN(CC6)C
InChI
1S/C37H37N5O4/c1-26-11-13-27(14-12-26)30-7-3-4-8-31(30)36(45)38-29-17-15-28(16-18-29)37(46)41-20-19-34(43)42(33-10-6-5-9-32(33)41)25-35(44)40-23-21-39(2)22-24-40/h3-18H,19-25H2,1-2H3,(H,38,45)
InChIKey
IOISKVCNGOOFMR-UHFFFAOYSA-N
CAS Number
CAS 168046-41-1
PubChem Compound ID
9873768
PubChem Substance ID
14838745, 24163621, 45296025, 79785849, 85218772, 128196915, 134340031, 142988213, 224999487, 232398079
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [535608]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 535608Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.
Ref 535608Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210.

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