Drug Information

Drug General Information
Drug ID
D0E4WR
Former ID
DAP000889
Drug Name
Azelaic Acid
Synonyms
AZA; Azelaic; Azelex; Finacea; Finevin; Skinorem; Skinoren; Acide azelaique; Acide azelaique [French]; Acido azelaico; Acido azelaico [Spanish]; Acidum azelaicum; Acidum azelaicum [Latin]; Anchoic acid; Azalaic Acid; Azelaic acid polyanhydride; Azelaic polyanhydride; Azelainic acid; Azleaic Acid; Heptanedicarboxylic acid; Lepargylic acid; NONANEDIOIC ACID; Nonanedioic acid; Polyazelaic anhydride; AZ1; Dicarboxylic acid C9; Emerox 1110; Emerox 1144; ZK 62498; A-9800; AGN-191861; Azelaic acid [USAN:INN]; Azelaic acid,technical grade; Azelex (TN); Finacea (TN); Finevin (TN); N-Nonanedioic acid; Nonanedioic acid, homopolymer; Poly(azelaic anhydride); SH-441; Skinoren (TN); ZK-62498; AZELAIC ACID, 95%; Azelaic acid (USAN/INN); Emery's L-110; 1,7-Heptanedicarboxylic acid; 1,9-Nonanedioic acid
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Approved [528549], [542507], [551871]
Therapeutic Class
Dermatologic Agents
Structure
Download
2D MOL

3D MOL
Formula
C9H16O4
InChI
InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
InChIKey
BDJRBEYXGGNYIS-UHFFFAOYSA-N
CAS Number
CAS 123-99-9
PubChem Compound ID
2266
PubChem Substance ID
10460, 82388, 598328, 833095, 3132046, 4503339, 7886019, 8139926, 8149608, 8151524, 10506000, 11110663, 11335707, 11360946, 11362851, 11365413, 11367975, 11371356, 11373801, 11376137, 11461918, 11484825, 11488811, 11490094, 11492216, 11493871, 11528613, 11537636, 12013195, 14710853, 15195285, 17397189, 17404615, 24278221, 24869448, 24891477, 26612002, 26679444, 26747429, 26747430, 26747431, 26753510, 29221439, 46393271, 46506284, 46530506, 47515289, 47885374, 48035077, 48334457
ChEBI ID
ChEBI:48131
SuperDrug ATC ID
D10AX03
SuperDrug CAS ID
cas=000123999
Target and Pathway
Target(s) 5-alpha reductase Target Info Inhibitor [537740]
References
Ref 528549Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs. 1991 May;41(5):780-98.
Ref 542507(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7484).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537740Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32.

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