Drug Information

Drug General Information
Drug ID
D03KQF
Former ID
DAP001150
Drug Name
Maprotiline
Synonyms
Deprilept; Dibencycladine; Maprotilin; Maprotilina; Maprotilinum; Maprotylina; Maprotylina [Polish]; TBB066626; BA-34276; Deprilept (TN); Ludiomil (TN); Maprotilina [INN-Spanish]; Maprotiline (USAN); Maprotilinum [INN-Latin]; Psymion (TN); Ba-34,276; Maprotiline [USAN:BAN:INN]; N-Methyl-9,10-ethanoanthracene-9(10H)-propanamine; N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine; 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)propylmethylamine; 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Approved [551871]
Therapeutic Class
Antidepressants
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL
Formula
C20H23N
InChI
InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
InChIKey
QSLMDECMDJKHMQ-UHFFFAOYSA-N
CAS Number
CAS 10262-69-8
PubChem Compound ID
4011
PubChem Substance ID
9318, 5663164, 7849638, 7979861, 8152515, 10502561, 11111502, 11112599, 11113802, 11336066, 11361305, 11363781, 11366343, 11368905, 11371545, 11373608, 11377067, 11462277, 11466374, 11467494, 11483954, 11486068, 11487955, 11490299, 11491850, 11494701, 14775197, 17396737, 26751977, 28476385, 29223122, 46508358, 47211277, 47291194, 47589054, 47662343, 47662542, 47736549, 47811030, 47885658, 48035199, 48259301, 49699342, 49967387, 50085871, 50100934, 50104649, 57322094, 74719609, 85209857
SuperDrug ATC ID
N06AA21
SuperDrug CAS ID
cas=010262698
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [536083]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536083Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets. Gen Physiol Biophys. 2005 Mar;24(1):113-28.

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