Drug Information

Drug General Information
Drug ID
D08FTG
Former ID
DAP000769
Drug Name
Phenindione
Synonyms
Athrombon; Bindan; Cronodione; Danedion; Danilon; Danilone; Diadilan; Dindevan; Dineval; Diophindane; Emandion; Emandione; Eridione; Fenhydren; Fenilin; Fenindion; Fenindiona; Hedulin; Hemolidione; Indema; Indion; Indon; Phenhydren; Phenillin; Phenindionum; Phenylen; Phenylin; Phenylindanedione; Phenylindione; Phenyline; Phenyllin; Pindione; Rectadione; Theradione; Thrombasal; Tromazal; Trombol; Boots Brand of Phenindione; Goldshield Brand of Phenindione; Merck Lipha Sante Brand of Phenindione; P1029; P26406_ALDRICH; Fenindiona [INN-Spanish]; Hedulin (TN); Phenindione (INN); Phenindione [INN:BAN]; Phenindionum [INN-Latin]; 2 Phenyl 1,3 indandione; 2-Fenyloindandion-1,3; 2-Fenyloindandion-1,3 [Polish]; 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3-indandione; 2-Phenyl-1,3-indanedione; 2-Phenyl-1H-indene-1,3(2H)-dione; 2-Phenylindan-1,3-dione; 2-Phenylindandione; 2-phenyl-1,3(2H)-Indenedione; 2-phenyl-2,3-dihydro-1H-indene-1,3-dione; 2-phenylindene-1,3-dione
Drug Type
Small molecular drug
Indication Pulmonary embolism; Blood clotting disorder [ICD9: 415.1, 286; ICD10:I26, D65-D69] Approved [541918], [550721], [551871]
Therapeutic Class
Anticoagulants
Structure
Download
2D MOL

3D MOL
Formula
C15H10O2
InChI
InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
InChIKey
NFBAXHOPROOJAW-UHFFFAOYSA-N
CAS Number
CAS 83-12-5
PubChem Compound ID
4760
PubChem Substance ID
9786, 96470, 592770, 3140660, 4437707, 7980289, 8145933, 8149475, 8152921, 10321812, 10536726, 11112218, 11335482, 11360721, 11363821, 11366383, 11368945, 11371819, 11374091, 11377107, 11461693, 11466566, 11467686, 11484833, 11486212, 11488815, 11490526, 11492291, 11494741, 11532881, 14797982, 24898344, 26611868, 26679622, 26748198, 26748199, 28325577, 29223844, 46505018, 47365097, 47365098, 47588902, 47662190, 47662191, 48110361, 48184902, 48334394, 48416412, 49698721, 49982286
ChEBI ID
ChEBI:8066
SuperDrug ATC ID
B01AA02
SuperDrug CAS ID
cas=000083125
Target and Pathway
Target(s) Vitamin K epoxide reductase complex subunit 1 Target Info Inhibitor [536520]
KEGG Pathway Ubiquinone and other terpenoid-quinone biosynthesis
PathWhiz Pathway Vitamin K Metabolism
Coagulation
WikiPathways PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
References
Ref 541918(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6838).
Ref 550721Drug information of Phenindione, 2008. eduDrugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536520Oral anticoagulation and pharmacogenetics: importance in the clinical setting. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.

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