Drug Information

Drug General Information
Drug ID
D0QV5T
Former ID
DAP000771
Drug Name
Phenprocoumon
Synonyms
Falithiom; Falithrom; Fencumar; Fenprocoumona; Fenprocumon; Fenprocumone; Liquamar; Marcoumar; Marcumar; Marcuphen; Phenprocoumalol; Phenprocoumarol; Phenprocoumarole; Phenprocoumone; Phenprocoumonum; Phenprocumone; Phenprocumonum; Phenprogramma; Phenylpropylhydroxycumarinum; Fenprocumone [DCIT]; Hexal Brand of Phenprocoumon; Roche Brand of Phenprocoumon; Worwag Brand of Phenprocoumon; U29342; Falithrom (TN); Fenprocoumona [INN-Spanish]; Liquamar (TN); Marcoumar (TN); Marcumar (TN); Phenprocoumone [INN-French]; Phenprocoumonum [INN-Latin]; Ro 1-4849; Phenprocoumon (USAN/INN); Phenprocoumon [USAN:INN:BAN]; 2-hydroxy-3-(1-phenylpropyl)chromen-4-one; 3-(1'-Phenyl-propyl)-4-oxycoumarin; 3-(1'-Phenyl-propyl)-4-oxycoumarin [German]; 3-(1-Phenylpropyl)-4-hydroxycoumarin; 3-(alpha-Ethylbenzyl)-4-hydroxycoumarin; 3-(alpha-Phenylpropyl)-4-hydroxycoumarin; 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Approved [538444], [541919], [551871]
Therapeutic Class
Anticoagulants
Structure
Download
2D MOL

3D MOL
Formula
C18H16O3
InChI
InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3
InChIKey
DQDAYGNAKTZFIW-UHFFFAOYSA-N
CAS Number
CAS 435-97-2
PubChem Compound ID
54680692
PubChem Substance ID
612021, 7845703, 7980293, 8030662, 10522853, 14848717, 29228465, 42684251, 46506423, 47207126, 47815891, 48416418, 49956264, 56394971, 57309600, 57325861, 76965160, 93302774, 103179879, 103950577, 104253508, 104321863, 106673762, 125823525, 126658557, 127770897, 134338056, 134974499, 135692445, 137126448, 137239431, 142971044, 160964285, 162011455, 162224643, 162652374, 163418248, 164042860, 174529392, 176262013, 178103445, 179326620, 184545898, 186014484, 198993025, 219400682, 223670210, 223705291, 226427577, 227840593
ChEBI ID
ChEBI:50438
SuperDrug ATC ID
B01AA04
SuperDrug CAS ID
cas=000435972
Target and Pathway
Target(s) Vitamin K epoxide reductase complex subunit 1 Target Info Inhibitor [536520]
KEGG Pathway Ubiquinone and other terpenoid-quinone biosynthesis
PathWhiz Pathway Vitamin K Metabolism
Coagulation
WikiPathways PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
References
Ref 538444FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011228.
Ref 541919(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6839).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536520Oral anticoagulation and pharmacogenetics: importance in the clinical setting. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.

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