Drug Information

Drug General Information
Drug ID
D08MJO
Former ID
DCL000743
Drug Name
CDP323
Drug Type
Small molecular drug
Indication Multiple sclerosis; Rheumatoid arthritis [ICD9: 340, 710-719, 714; ICD10:G35, M00-M25, M05-M06] Phase 2 [536651]
Company
UCB; Biogen Idec
Structure
Download
2D MOL

3D MOL
Formula
C26H25BrN4O3
Canonical SMILES
C1CCC2(CC1)C(=C(C2=O)Br)NC(CC3=CC=C(C=C3)NC4=NC=CC5=C4C<br />=NC=C5)C(=O)O
InChI
1S/C26H25BrN4O3/c27-21-22(26(23(21)32)10-2-1-3-11-26)31-20(25(33)34)14-16-4-6-18(7-5-16)30-24-19-15-28-12-8-17(19)9-13-29-24/h4-9,12-13,15,20,31H,1-3,10-11,14H2,(H,29,30)(H,33,34)/t20-/m0/s1
InChIKey
KYHVWHYLKOHLKA-FQEVSTJZSA-N
PubChem Compound ID
10186367
PubChem Substance ID
15181855, 22581016, 40275937, 80102127, 135266685, 143366321, 152258896, 160647744, 160832430, 163095502, 163397642, 163843958, 186014836, 189659313, 198982723, 204429939, 229034759, 248696803, 252494948
Target and Pathway
Target(s) Integrin alpha-4/beta-1 Target Info Modulator
KEGG Pathway PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Regulation of actin cytoskeleton
Leishmaniasis
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
Reactome Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
WikiPathways Focal Adhesion
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
References
Ref 536651Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.

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