Drug Information

Drug General Information
Drug ID
D09ELW
Former ID
DNC000604
Drug Name
Enalkiren
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Discontinued in Phase 2 [544632]
Structure
Download
2D MOL

3D MOL
Formula
C35H56N6O6
Canonical SMILES
CC(C)CC(C(C(CC1CCCCC1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC<br />=C(C=C3)OC)NC(=O)CC(C)(C)N)O)O
InChI
1S/C35H56N6O6/c1-22(2)15-30(42)32(44)27(16-23-9-7-6-8-10-23)40-34(46)29(18-25-20-37-21-38-25)41-33(45)28(39-31(43)19-35(3,4)36)17-24-11-13-26(47-5)14-12-24/h11-14,20-23,27-30,32,42,44H,6-10,15-19,36H2,1-5H3,(H,37,38)(H,39,43)(H,40,46)(H,41,45)/t27-,28-,29-,30-,32+/m0/s1
InChIKey
KQXVERRYBYGQJZ-WRPDIKACSA-N
CAS Number
CAS 113082-98-7
PubChem Compound ID
60594
PubChem Substance ID
9669, 7980346, 12014324, 15262178, 17397827, 43117973, 46505948, 50064177, 50911723, 57314040, 103231502, 103919626, 104321170, 126666441, 134339995, 135018409, 135842305, 137147631, 143382590, 160966520, 164840950, 179149611, 184547480, 223439604, 223655283, 223860361, 226494252
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [537925]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 544632Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000369)
Ref 537925Comparative effects of three different potent renin inhibitors in primates. Hypertension. 1993 Jul;22(1):9-17.

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