Drug General Information
Drug ID
D05QKO
Former ID
DIB012863
Drug Name
NBI-5788
Synonyms
Tiplimotide; CGP-77116; MSP-771; MSP-771A; APL (multiple sclerosis), Neurocrine/Novartis; Altered peptide ligand (MS), Neurocrine/Novartis
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Phase 2 [521426]
Company
Neurocrine Biosciences Inc
Structure
Download
2D MOL

3D MOL

Formula
C87H142N24O21
Canonical SMILES
C(=O)(N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O<br />)O)CCC2)[C@H](O)C)CCCNC(=N)N)CCC1)[C@@H](NC(=O)[C@@H](N<br/>C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=<br />O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[<br />C@H]1N(C(=O)[C@@H](NC(=O)[C@H](N)C)CCCCN)CCC1)C(C)C)C(C<br />)C)Cc1nc[nH]c1)CC(C)C)Cc1ccccc1)C)CC(=O)N)[C@H](CC)C)C(<br />C)C)[C@H](O)C
PubChem Compound ID
Target and Pathway
Target(s) Myelin basic protein Target Info Binder [525908]
WikiPathways MAPK Cascade
Structural Pathway of Interleukin 1 (IL-1)
Spinal Cord Injury
Glial Cell Differentiation
Neural Crest Differentiation
References
Ref 521426ClinicalTrials.gov (NCT00001781) Safety, Tolerability, and Effectiveness of CGP77116 in Patients With Multiple Sclerosis (MS). U.S. National Institutes of Health.
Ref 525908NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol. 2000 Nov;48(5):758-65.

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