Drug General Information
Drug ID	D0N8AB
Former ID	DIB012025
Drug Name	PF-4629991
Synonyms	PF-991; S1P1 receptor agonist (autoimmune disease), Pfizer
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Discontinued in Phase 1	[548892]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1c(onc1c1ccc(cc1)[C@H](N[C@@H]1C[C@@H](C1)C(=O)O)C)c1c<br />cc(cc1)CC(C)C
Target and Pathway
Target(s)	Sphingosine 1-phosphate receptor 1	Target Info	Agonist	[551919]
KEGG Pathway	FoxO signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL2 Signaling Pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	S1P3 pathway
	S1P1 pathway
	Sphingosine 1-phosphate (S1P) pathway
	PDGFR-beta signaling pathway
Reactome	G alpha (i) signalling events
	Lysosphingolipid and LPA receptors
WikiPathways	Signal Transduction of S1P Receptor
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 548892	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030004)
Ref 551919	US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.

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