Drug Information

Drug General Information
Drug ID
D0WV3U
Former ID
DAP000300
Drug Name
Prazosin
Synonyms
Furazosin; Justac; Lentopres; Prazocin; Prazosina; Prazosine; Prazosinum; Prazosin HCl; TNP00312; CP-12299; Hypovase (TN); Minipress (TN); Prazosin (INN); Prazosin [INN:BAN]; Prazosina [INN-Spanish]; Prazosine [INN-French]; Prazosinum [INN-Latin]; Vasoflex (TN); [3H]-Prazosin; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone; [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone; [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone; Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI); Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI); 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine; 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline; 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone
Drug Type
Small molecular drug
Indication Hypertension; Symptomatic benign prostatic hyperplasia; Severe congestive heart failure [ICD10:I10-I16] Approved [551871]
Therapeutic Class
Antihypertensive Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H21N5O4
InChI
InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
InChIKey
IENZQIKPVFGBNW-UHFFFAOYSA-N
CAS Number
CAS 19216-56-9
PubChem Compound ID
4893
PubChem Substance ID
9572, 841974, 4500854, 7980376, 8153011, 11112649, 11112650, 11113367, 11120245, 11120733, 11121221, 11121703, 11122183, 11335550, 11360789, 11362790, 11363716, 11365352, 11366278, 11367914, 11368840, 11370831, 11370832, 11371821, 11373515, 11374104, 11376076, 11377002, 11406810, 11461761, 11466975, 11468095, 11485033, 11486809, 11489105, 11490367, 11492298, 11494636, 14804776, 26751613, 26751614, 29223971, 46508594, 47364941, 47364942, 47588782, 47662032, 47662033, 47662034, 47662035
ChEBI ID
ChEBI:8364
SuperDrug ATC ID
C02CA01
SuperDrug CAS ID
cas=019216569
Target and Pathway
Target(s) Alpha-1 adrenergic receptor Target Info Antagonist [535260], [537558]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535260Characterization of alpha-adrenoceptor subtypes in smooth muscle of equine ileum. Am J Vet Res. 2001 Sep;62(9):1370-4.
Ref 537558Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Auton Autacoid Pharmacol. 2009 Jul;29(3):117-33.

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