Drug Information
Drug General Information | |||||
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Drug ID |
D05FYA
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Former ID |
DNC001435
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Drug Name |
Thioperamide
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C15H24N4S
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InChI |
InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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InChIKey |
QKDDJDBFONZGBW-UHFFFAOYSA-N
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CAS Number |
CAS 106243-16-7
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PubChem Compound ID | |||||
PubChem Substance ID |
5646740, 5849660, 11111845, 11113618, 14922585, 14922586, 24536774, 26751818, 36104185, 47721703, 49846728, 50015455, 50104511, 51054761, 57353295, 85083113, 85209332, 85788104, 90341317, 96024154, 99206112, 103566780, 103941424, 111640044, 124750325, 124881519, 124881520, 124881521, 126591031, 129034527, 134340541, 134340617, 135143800, 135651258, 135698493, 135756358, 137185856, 142231014, 142667105, 179149541, 179235817, 184581023, 198982124, 223446365, 228362787, 241181796, 241377426, 249617185, 250134232
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Target and Pathway | |||||
Target(s) | Histamine H3 receptor | Target Info | Antagonist | [534934], [536039] | |
Histamine H4 receptor | Target Info | Antagonist | [536039], [536681], [536849] | ||
References | |||||
Ref 538782 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1267). | ||||
Ref 545719 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004362) | ||||
Ref 534934 | Combined histamine H1 and H3 receptor blockade produces nasal decongestion in an experimental model of nasal congestion. Am J Rhinol. 1999 Sep-Oct;13(5):391-9. | ||||
Ref 536039 | The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. | ||||
Ref 536681 | Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury. Neuroimmunomodulation. 2007;14(6):317-25. Epub 2008 Apr 10. | ||||
Ref 536849 | Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86. Epub 2008 Sep 11. |
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