Drug Information

Drug General Information
Drug ID
D03ZVW
Former ID
DIB011405
Drug Name
Vapiprost
Synonyms
Vapiprost hydrochloride; GR-32191; GR-32191B; SN-309
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Terminated [539272], [544530]
Company
GlaxoSmithKline KK
Structure
Download
2D MOL

3D MOL
Formula
C30H39NO4
InChI
InChI=1S/C30H39NO4/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34)/b2-1-/t26-,27-,28-,30+/m0/s1
InChIKey
GQGRDYWMOPRROR-XUSMOFMBSA-N
PubChem Compound ID
6918030
PubChem Substance ID
14834633, 14858953, 23950796, 43529430, 50104970, 50298506, 85787635, 103256597, 104124723, 114787327, 135049550, 135650318, 135695331, 198967823, 226415852
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Modulator [544028]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539272(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1976).
Ref 544530Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000070)
Ref 544028Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator.. Br J Pharmacol. 1992 July; 106(3): 533-538.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.