Drug Information
Drug General Information | |||||
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Drug ID |
D02SKA
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Former ID |
DIB014627
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Drug Name |
FCE-22716
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Synonyms |
1-(6-Methylergolin-8beta-yl)hydantoin; 1-[[(8beta)-6-Methylergolin-8-yl]methyl]-2,4-imidazolidinedione; 7beta-(2,4,-Dioxo-1-imidazolidinylmethyl)-9-methyl-2,5balpha,6,7,8,9,9abeta,10-octahydroindolo[4,3a,3-f,g]quinoline; 8beta-(2,4-Dioxo-1-imidazolidinylmethyl)-6-methylergoline
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Discontinued in Phase 2 | [533340] | ||
Structure |
Download2D MOL |
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Formula |
C19H22N4O2
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Canonical SMILES |
CN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CN5CC(=O)NC5=O
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InChI |
1S/C19H22N4O2/c1-22-8-11(9-23-10-17(24)21-19(23)25)5-14-13-3-2-4-15-18(13)12(7-20-15)6-16(14)22/h2-4,7,11,14,16,20H,5-6,8-10H2,1H3,(H,21,24,25)/t11-,14-,16-/m1/s1
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InChIKey |
VXIHQTMCLKWCBN-DJSGYFEHSA-N
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CAS Number |
CAS 95688-34-9
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 2A receptor | Target Info | Antagonist | [526792], [533340] | |
Alpha-1D adrenergic receptor | Target Info | Modulator | [533340] | ||
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway | |||||
cGMP-PKG signaling pathway | |||||
Adrenergic signaling in cardiomyocytes | |||||
Vascular smooth muscle contraction | |||||
Salivary secretion | |||||
NetPath Pathway | IL2 Signaling Pathway | ||||
PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, OtherWP58:Monoamine GPCRs | |||||
Calcium Regulation in the Cardiac Cell | |||||
GPCRs, Other | |||||
References |
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