Drug Information

Drug General Information
Drug ID
D05UMD
Former ID
DIB014591
Drug Name
R-87366
Synonyms
Quinoxalin-2-ylcarbonyl-L-asparaginyl-[3(S)-amino-2(S)-hydroxy-4-phenylbutyryl]-L-proline tert-butylamide
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 2 [546555]
Structure
Download
2D MOL

3D MOL
Formula
C32H39N7O6
Canonical SMILES
CC(C)(C)NC(=O)C1CCCN1C(=O)C(C(CC2=CC=CC=C2)NC(=O)C(CC(=<br />O)N)NC(=O)C3=NC4=CC=CC=C4N=C3)O
InChI
1S/C32H39N7O6/c1-32(2,3)38-30(44)25-14-9-15-39(25)31(45)27(41)22(16-19-10-5-4-6-11-19)36-28(42)23(17-26(33)40)37-29(43)24-18-34-20-12-7-8-13-21(20)35-24/h4-8,10-13,18,22-23,25,27,41H,9,14-17H2,1-3H3,(H2,33,40)(H,36,42)(H,37,43)(H,38,44)/t22-,23-,25-,27-/m0/s1
InChIKey
UYZMZENNYRSFDS-QNWDWTFCSA-N
CAS Number
CAS 144779-91-9
PubChem Compound ID
464206
PubChem Substance ID
616731, 10304547, 14814091, 57405566, 77364564, 109738219, 135246995, 142603264, 240472753, 244448300
Target and Pathway
Target(s) HIV protease Target Info Inhibitor [534336], [551871]
References
Ref 546555Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008914)
Ref 534336In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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