Drug Information

Drug General Information
Drug ID
D06KOL
Former ID
DIB004625
Drug Name
Napitane mesilate
Synonyms
A-75200; ABT-200; Napitane mesilate < Prop INNM; Rac-1-[5,6-(Methylenedioxy)-1,2,3,4-tetrahydronaphth-1(R*)-ylmethyl]-3(R*)-phenylpyrrolidine methanesulfonate; Rac-3(R*)-Phenyl-1-[6,7,8,9-tetrahydronaphtho[1,2-d]-1,3-dioxol-6(R*)-ylmethyl]pyrrolidine methanesulfonate
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Discontinued in Phase 2 [545865]
Structure
Download
2D MOL

3D MOL
Formula
C22H25NO2
Canonical SMILES
C1CC(C2=C(C1)C3=C(C=C2)OCO3)CN4CCC(C4)C5=CC=CC=C5
InChI
1S/C22H25NO2/c1-2-5-16(6-3-1)17-11-12-23(13-17)14-18-7-4-8-20-19(18)9-10-21-22(20)25-15-24-21/h1-3,5-6,9-10,17-18H,4,7-8,11-15H2
InChIKey
HAEPGZUGYMHCJE-UHFFFAOYSA-N
CAS Number
CAS 125067-61-0
PubChem Compound ID
60932
PubChem Substance ID
15348120, 17186385, 43118251, 51843083, 85213107, 103195430, 104321978, 117603182, 126422408, 135235906, 179322967
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Modulator
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 545865Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005107)

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